IDENTIFICATION OF TRANSTHYRETIN BINDING DRUGS WITH POTENTIAL THERAPEUTIC USAGE IN HEREDO FAMILIAL AMYLOIDOSIS

Pubblicazioni Scientifiche

• 1999-09-01 AMERICAN JOURNAL OF PATHOLOGY

  The new apolipoprotein A-I variant Leu174 → Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93-residue N-terminal polypeptide

• 2000-06-01 AMERICAN JOURNAL OF PATHOLOGY

  4′-iodo-4′-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid

• 1999-06-01 CELLULAR AND MOLECULAR LIFE SCIENCES

  Biological activity and pathological implications of misfolded proteins

• 2000-09-01 ELECTROPHORESIS

  Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis

• 2004-02-01 JOURNAL OF INTERNAL MEDICINE

  The systemic amyloidoses: clearer understanding of the molecular mechanisms offers hope for more effective therapies

• 2000-05-01 PROTEIN SCIENCE

  Removal of the N-terminal hexapeptide from human β2-microglobulin facilitates protein aggregation and fibril formation