Indagine sul ruolo delle membrane mitocondriali nell’innesco del processo della perdita cellulare nella malattia di Huntington: pazienti, modelli animali e meccanismi molecolari
- 3 Anni 2006/2009
- 391.900€ Totale Fondi
Le cause che determinano la malattia neurodegenerativa chiamata corea di Huntington sono ancora in gran parte sconosciute. È stato ipotizzato che alterazioni della funzionalità dei mitocondri, la fonte energetica delle cellule, siano la causa dei sintomi osservati in questa patologia. L’idea è che questi cambiamenti determinino come evento finale una morte delle cellule per autofagia. Questo progetto si propone di analizzare sia il ruolo sia le eventuali alterazioni dei mitocondri nell’Huntington, al fine di definire nuovi approcci terapeutici.
Pubblicazioni Scientifiche
- 2012-05-01 AMINO ACIDS
TG2 transamidating activity acts as a reostat controlling the interplay between apoptosis and autophagy
- 2009-04-01 APOPTOSIS
New insights on the role of apoptosis and autophagy in HIV pathogenesis
- 2009-11-16 AUTOPHAGY
Transglutaminase 2 is involved in autophagosome maturation
- 2011-01-01 AUTOPHAGY
Cystic fibrosis
- 2006-09-01 BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
"Tissue" transglutaminase contributes to the formation of disulphide bridges in proteins of mitochondrial respiratory complexes
- 2008-07-01 CANCER RESEARCH
Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress
- 2009-08-01 CELL DEATH AND DIFFERENTIATION
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
- 2009-11-01 CELL DEATH AND DIFFERENTIATION
The adenine nucleotide translocator 1 acts as a type 2 transglutaminase substrate: implications for mitochondrial-dependent apoptosis
- 2010-06-01 CELL DEATH AND DIFFERENTIATION
Association of fission proteins with mitochondrial raft-like domains
- 2010-11-01 CELL DEATH AND DIFFERENTIATION
Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA
- 2010-05-01 CELLULAR AND MOLECULAR LIFE SCIENCES
Regulation of autophagy in mammals and its interplay with apoptosis
- 2010-09-17 CIRCULATION RESEARCH
Two Close, Too Close Sarcoplasmic Reticulum-Mitochondrial Crosstalk and Cardiomyocyte Fate
- 2010-12-01 EMBO MOLECULAR MEDICINE
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
- 2010-08-01 EXPERT REVIEW OF PROTEOMICS
Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases
- 2009-04-01 FASEB JOURNAL
Cell sex: a new look at cell fate studies
- 2009-10-01 FASEB JOURNAL
Raft component GD3 associates with tubulin following CD95/Fas ligation
- 2008-03-05 FEBS LETTERS
Redox state and gender differences in vascular smooth muscle cells
- 2008-02-15 JOURNAL OF IMMUNOLOGY
Transglutaminase type II is involved in the pathogenesis of endotoxic shock
- 2010-11-01 JOURNAL OF INTERNAL MEDICINE
Type 2 transglutaminase in Huntington's disease: a double-edged sword with clinical potential
- 2010-07-01 JOURNAL OF LEUKOCYTE BIOLOGY
Characterization of transglutaminase type II role in dendritic cell differentiation and function
- 2007-01-01 JOURNAL OF NEUROCHEMISTRY
Transglutaminase 2 ablation leads to defective function of mitochondrial respiratory complex I affecting neuronal vulnerability in experimental models of extrapyramidal disorders
- 2012-04-01 NEUROBIOLOGY OF AGING
Autoantibodies to the adenosine triphosphate synthase play a pathogenetic role in Alzheimer's disease
- 2010-12-01 NEUROBIOLOGY OF DISEASE
Characterization of gene expression induced by RTN-1C in human neuroblastoma cells and in mouse brain
- 2009-10-01 ONCOGENE
Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors
- 2013-07-11 ONCOGENE
Ambra1 at the crossroad between autophagy and cell death
- 2010-01-05 PLOS ONE
Role of GD3-CLIPR-59 Association in Lymphoblastoid T Cell Apoptosis Triggered by CD95/Fas
- 2008-01-01 PROGRAMMED CELL DEATH, GENERAL PRINCIPLES FOR STUDYING CELL DEATH, PT A
More than two sides of a coin? How to detect the multiple activities of type 2 transglutaminase
