PED, A NOVEL GENE CONTROLLING GLUCOSE TRANSPORT IN MAMMALIAN CELLS: ITS ROLE IN TYPE 2 DIABETES

Pubblicazioni Scientifiche

• 2001-02-01 CANCER RESEARCH

  Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells

• 2000-07-01 DIABETES

  The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver (Publication with Expression of Concern. See vol. 67, pg. 345, 2018) (Retracted article. See vol. 68, pg. 464, 2019)

• 2001-06-01 DIABETES

  Protein kinase C (PKC)-α activation inhibits PKC-ζ and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells (Publication with Expression of Concern. See vol. 67, 2018) (Retracted article. See vol. 68, pg. 464, 2019)

• 1998-07-15 EMBO JOURNAL

  PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

• 1999-10-01 JOURNAL OF BIOLOGICAL CHEMISTRY

  In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-α and trans-activates the insulin receptor kinase

• 2001-10-05 JOURNAL OF BIOLOGICAL CHEMISTRY

  Insulin receptor substrate-2 phosphorylation is necessary for protein kinase Cζ activation by insulin in L6hIR cells

• 2001-11-30 JOURNAL OF BIOLOGICAL CHEMISTRY

  Activation and mitochondrial translocation of protein kinase Cδ are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells

• 2002-03-29 JOURNAL OF BIOLOGICAL CHEMISTRY

  Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

• 2002-07-12 JOURNAL OF BIOLOGICAL CHEMISTRY

  Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells

• 2002-07-05 JOURNAL OF BIOLOGICAL CHEMISTRY

  Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells

• 2004-03-19 JOURNAL OF BIOLOGICAL CHEMISTRY

  Protein kinase C-ζ and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting

• 2004-11-05 JOURNAL OF BIOLOGICAL CHEMISTRY

  Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

• 2000-09-01 MOLECULAR AND CELLULAR BIOLOGY

  Insulin-activated protein kinase Cβ bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells

• 2004-06-01 MOLECULAR AND CELLULAR BIOLOGY

  Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

• 2003-05-15 ONCOGENE

  Protein kinase Cα activation by RET:: evidence for a negative feedback mechanism controlling RET tyrosine kinase